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Colin Kaepernick leads 49ers over Jaguars 42-10 in London

  • San Francisco 49ers quarterback Colin Kaepernick runs during the NFL football game against the Jacksonville Jaguars at Wembley Stadium, London, Sunday, Oct. 27, 2013. (AP Photo/Matt Dunham)

LONDON — He ran. He threw. He conquered.

Colin Kaepernick did it all Sunday, rushing for two touchdowns and throwing for another to lead the San Francisco 49ers to their fifth straight victory, 42-10 over the winless Jacksonville Jaguars at Wembley Stadium.

"The offensive line did a great job, made it easy for me," said Kaepernick, who led the 49ers to the Super Bowl last year. "I think this is one of the first game that we started that fast."

San Francisco 49ers vs. Jacksonville Jaguars

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Kaepernick ended up with 164 yards passing and 54 yards rushing, Frank Gore also ran for two scores and 71 yards, while Kendall Hunter rushed for 84 yards for the 49ers (6-2).

But it was Kaepernick that made the key plays by when the team needed it early.

"He looked much like a running back, and that's great courage," 49ers coach Jim Harbaugh said. "You don't always see that in the quarterback position. As soon as he saw that window, he had a great dart and speed to get the ball into the end zone."

The Jaguars (0-8) were the "home" team at London's iconic soccer venue, playing in the British capital for the first of their four-year run of regular-season NFL games in London.

They had plenty of fan support, too, with many of the 83,559 spectators waving their giveaway Jaguars flags throughout the evening.

None of that affected what was happening on the field, and on the field it wasn't pretty for the Jags.

"Our season's not over," Jaguars receiver Justin Blackmon. "We're not going to just go out there and get our (butts) kicked, we're going to go back out there and fight."

Kaepernick made his first big play on San Francisco's first possession, quickly throwing to fullback Bruce Miller on the right sideline for a 43-yard gain.

A few plays later, Kaepernick scrambled for 4 1/2 yards on a third-and 5, setting up Gore for a short gain and a first down.

After an incomplete pass, Gore ran 19 yards for the first touchdown.

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